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Folix 5 Tablet - (5mg)

Folix 5 Tablet - (5mg)

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Medicine Overview of Folix 5mg Tablet বাংলা English Indication Colorectal cancer, Methotrexate toxicity, Megaloblastic anaemia Adult Dose Oral Antidote for methotrexate...
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Ingredients

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Allergon Information

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Orders are not shipped or delivered on weekends or holidays.

Standard Shipping: 5-7 business days. Rates will be calculated at checkout.

Express Shipping: 2-3 business days. Rates will be calculated at checkout.

Delivery delays can occasionally occur due to unforeseen circumstances.

Storage Instructions

Diameter: 12 inches (30.5 cm)

Thickness: 1 inch (2.5 cm)

Packaging Dimensions: 12.5 x 12.5 x 1.5 inches

Weight: 500 grams (17.6 oz)

Shipping & Returns

Dry Goods: Store in a cool, dry place away from direct sunlight and moisture. Seal the packaging tightly after each use to preserve freshness.

Perishables: Refrigerate immediately upon receiving to maintain optimal freshness. Follow the specific storage temperature guidelines mentioned on the packaging.

Frozen Items: Keep frozen until ready to use. Follow the thawing instructions on the package for best results.

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For fresh or refrigerated items, use within [number of days] of opening.

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Categories: BulBul Modern Medicine Pharmacy , Das Modern Medical Pharmacy , Medicine & Pharmacy , Prity Model Medicine Pharmacy

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Medicine Overview of Folix 5mg Tablet

বাংলা
English
Indication
Colorectal cancer, Methotrexate toxicity, Megaloblastic anaemia
Adult Dose
Oral Antidote for methotrexate toxicity Adult: 15 mg every 6 hr for 10 doses starting 24 hr after the start of methotrexate infusion. Continue admin until serum levels of methotrexate is <0.05 micromolar. May also be given via IM/IV inj. Folate-deficient megaloblastic anaemia Adult: 15 mg daily. Intravenous Adjunct to fluorouracil in colorectal cancer Adult: 200 mg/m2 BSA by slow IV inj over at least 3 min followed by 370 mg/m2 fluorouracil by IV inj. Treatment is given for 5 consecutive days and repeated at intervals of 28 days for 2 courses. Subsequently, may repeat at 4-5 wkly intervals if...
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Contraindication
Hypersensitivity, pernicious anaemia and other megaloblastic anaemias secondary to vit B12-deficiency, intrathecal and intraventricular admin.
Mode of Action
Calcium folinate enters the cells as 5-methyl tetrahydrofolate and supplies the cofactor blocked by methotrexate. It stabilises the binding of 5-dUMP and thrymidylate synthetase, enhances flourouracil activity and neutralises the effects of folic acid antagonists such as methotrexate but increases those of 5-fluorouracil.
Precaution
Undiagnosed megaloblastic anaemia, folate dependent tumors; pregnancy. Monitor calcium levels in patients receiving combined 5-Fluorouracil/Folinic acid treatment. To be given parenterally in the presence of GI toxicity, nausea or vomiting. Monitor serum levels of methotrexate to determine the optimal dose and duration of folinic acid admin. Monitor CBC, electrolytes and liver function tests before and regularly during treatment.
Side Effect
Allergic sensitisation, rash, pruritus, eythema, urticaria, nausea, vomiting, pyrexia.
Interaction
Fluorouracil: Folinic acid may increase the toxicity associated with fluorouracil if the two are administered together. Some adverse effects that have occurred, particularly in elderly patients, include severe enterocolitis, diarrhea, and dehydration. Sulfamethoxazole-trimethoprim: A potential drug interaction exists with concomitant use of sulfamethoxazole-trimethoprim and folinic acid. Folinic acid has been shown to decrease the efficacy of sulfamethoxazole-trimethoprim in the treatment of pneumocystis carinii, a common cause of pneumonia in AIDs patients
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